Chronic viral hepatitis is a major cause of liver disease progression and cancer. Even though, viral infection can be cured or controlled a significant risk to develop liver cancer persist in patients. We have identified an epigenetic viral footprint of chronic viral hepatitis (HCV, HBV, HDV) that associates with viral pathogenesis and cancer risk the liver of infected human liver chimeric mice and patients. Importantly, this imprinting is persistently dysregulated even after viral cure and highlight candidate biomarker to identify patients at elevated risk to develop liver cancer and novel chemo-preventive targets to attenuate cancer risk.
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